Genetic Analysis of Ras Signaling Pathways in Cell Proliferation, Migration and Survival

Thank you for submitting your manuscript to the EMBO journal. Your study has now been seen by three referees and their comments to authors are provided below. As you can see, referee #2 is not persuaded that we gain enough new insight into how Ras proteins function in order to consider publication here. However, both referees #1 and 3 are more supportive and find the analysis interesting, insightful and suitable for publication in the EMBO Journal. Given the strong support provided by both those referees, I will go with their overall recommendation and ask you to submit a suitably revised manuscript for our consideration. In the revised version please extend the analysis along the lines as indicated by referees #1 and #3 and also keep in mind the specific points raised by referee #2. When you send us your revision, please include a cover letter with an itemised list of all changes made, or your rebuttal, in response to comments from review.